Lrp5 functions in bone to regulate bone mass
نویسندگان
چکیده
منابع مشابه
Wntless functions in mature osteoblasts to regulate bone mass.
Recent genome-wide association studies of individuals of Asian and European descent have found that SNPs located within the genomic region (1p31.3) encoding the Wntless (Wls)/Gpr177 protein are associated significantly with reduced bone mineral density. Wls/Gpr177 is a newly identified chaperone protein that specifically escorts Wnt ligands for secretion. Given the strong functional association...
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Background: LRP5 is a gene that encodes a widely expressed cell surface receptor that, together with the receptor Frizzled, forms a receptor complex for the family of Wnt ligands. LRP5, a member of the low density lipoprotein receptor (LDLR) family, has an important role in regulating bone mass. Loss-of-function mutations in LRP5 cause osteoporosis pseudoglioma, characterized by low bone mass a...
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The hypothalamus has been implicated in skeletal metabolism. Whether hunger-promoting neurons of the arcuate nucleus impact the bone is not known. We generated multiple lines of mice to affect AgRP neuronal circuit integrity. We found that mice with Ucp2 gene deletion, in which AgRP neuronal function was impaired, were osteopenic. This phenotype was rescued by cell-selective reactivation of Ucp...
متن کاملThe LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd.
The mechanism by which the high-bone-mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates canonical Wnt signaling was investigated. The mutation was previously shown to reduce DKK1-mediated antagonism, suggesting that the first YWTD repeat domain where G171 is located may be responsible for DKK-mediated antagonism. However, we found that the third YWTD repeat, but not the first repe...
متن کاملThe Effect of the LRP5 High Bone Mass Mutation under Bone Wasting Stimuli
INTRODUCTION: The low density lipoprotein receptor-related protein-5 (LRP5), a coreceptor in the Wnt signaling pathway, has been shown to be important in modulating bone mass in humans and in mice. Among humans, a loss of function mutation in LRP5 results in a severe osteoporotic disease, while certain missense mutations in the gene (gain-of-function mutations) result in a high bone mass (HBM) ...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2011
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm.2388